I'm sorry you're having problems losing weight. Hormones can wreak havoc on weight. The concept of losing weight before getting healthy is a misnomer. Therefore, I would recommend you focus on your health right now. As your body begins to heal, your weight will drop if you are indeed eating a healthy diet. As far as cleansing, I would never recommend detoxing your liver to begin. You should always start with a digestive/bowel cleanse. Without this particular cleanse, a liver cleanse will do nothing for you but possibly back you up with further toxins. Once you've completed a digestive/bowel cleanse and can eliminate three good stools per day, then a liver cleanse may be beneficial. Remember to always start from "bottom to top" and "inside to out" for detox cleanses. Regarding your estrogen issues, I would recommend chaste tree berry and maca to begin. They are two great botanical herbs for regulating a woman's hormone levels. It may take a few months of consistency to feel changes, but it is well worth the try. Please let me know how things for out for you.